Moderate to Severe Pain. 1-2 tablets (2.5-10 mg hydrocodone; 300-325 mg acetaminophen) PO q4-6hr PRN.can result in a fatal overdose of Hydrocodone Bitartrate and Acetaminophen Tablets [ ... Each Hydrocodone Bitartrate and Acetaminophen Tablet, 5 mg/325 mg.BACKGROUND: Hydrocodone 7.5 mg with ibuprofen 200 mg is the only ... those of a 2-tablet dose of oxycodone 5 mg and acetaminophen 325 mg and placebo.